Preparation and Characterization of Ethosomes for Topical Delivery of Clindamycin

Topical medication administration is the simplest and most convenient method of delivering localised drugs to any part body via ophthalmic, rectal, vaginal, cutaneous channels. These are used in a wide range cosmetic dermatological preparations on both healthy sick skin. Drugs applied topically have an effect at application site or systemic effects. The goal this study was develop characterise clindamycin ethosomes that could carry medicine target more efficiently while also avoiding complications associated with oral drug delivery. formulations were tested for vesicle size, shape, surface morphology, entrapment efficiency, vitro penetration using different amounts ethanol (10-50 percent), HPMC (1-4 PVC (5-20 percent). Transmission electron microscopy revealed average size 1.112m spherical shape smooth surface. maximum percentage entrapped 91.060.79%. total amount pierced biological membrane found be between 0.250.014 0.480.032 mg/cm2. stability profile constructed system evaluated 45 days, results very little degradation occurred during storage.
 Keywords: Clindamycin, Ethosomes, delivery, HPMC, Acne, Vesicle